«Smart ardor»: selective low-power IR-laser activation of conformational DNA transformations in bacteria for desinfection and sterilization Sergey I. Kudryashov,1,4 Victor Kompanets,2 Svetlana N. Shelygina,1 Eteri R. Tolordava,1,3-4 Andrey A. Ionin,2 Yulia K. Yushina,4 Sergey V. Chekalin,1 Michael S. Kovalev,5
1 Lebedev Physical Institute, Russian Academy of Sciences, Moscow, Russia
2 Institute of Spectroscopy, Russian Academy of Sciences, Troitsk, Russia
3Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, Russia
4 V.M. Gorbatov Federal Scientific Center for Food Systems, Russian Academy of Sciences, Moscow, Russia
5 Bauman Moscow State Technical University, Moscow, Russia
Mesoscopic early-photon fluorescence molecular lifetime tomography: first experimental results Alexander B. Konovalov,1,2 Vitaly V. Vlasov,1,2 Sergei I. Samarin,1 Ilya D. Soloviev,2 Alexander P. Savitsky2, Valery V. Tuchin,2,3,4,5
1 Federal State Unitary Enterprise “Russian Federal Nuclear Center – Zababakhin All-Russia Research Institute of Technical Physics,” Snezhinsk, Russia 2 Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Science, Moscow, Russia 3 Saratov State University, Saratov, Russia 4 Tomsk State University, Tomsk, Russia 5 Institute of Precision Mechanics and Control of the Russian Academy of Sciences, Saratov, Russia
Internet Invited Lecture
Optical coherence tomography for otitis media diagostics Pavel A. Shilyagin, 1 Alexey A. Novozhilov1,2 Tatiana V. Vasilenkova,1 Anait L. Dilenyan,1,2 Darya D. Smirnova, 1,2 Grigory V. Gelikonov,1 Valentin M. Gelikonov, 1
1 Institute of applied physics of RAS, Nizhny Novgorod, Russia
2 Privolzhsky region medical center of Russian FMBA, Nizhny Novgorod, Russia
FUNCTIONAL NEAR-INFRARED SPECTROSCOPY BRAIN RESEARCH IN CLINICAL SETTINGS Teemu Myllylä
Research Unit of Medical Imaging, Physics and Technology,
Faculty of Medicine
&
Optoelectronics and Measurement Techniques Research Unit,
Faculty of Information Technology and Electrical Engineering,
University of Oulu, Oulu, Finland
Biophotonics study of cells interaction in blood under normal and pathological conditions Alexander Priezzhev,1, Andrei Lugovtsov,1, Petr Ermolinskiy,1, Irina Kadanova,1, Anton Neznanov,1, Yuri Gurfinkel,3 and Alexey Semenov,2
1 Faculty of Physics, 2 Faculty of Biology, 3 Medical Research and Education Center
of Lomonosov Moscow State University, 119991 Moscow, Russia
Advantages of the Compact Permanent Preclinical MRI Topic:
Aspect Imaging Compact:
Advantages of the Compact Permanent Preclinical MRI
Speaker Name :Kobi Katsobashvili MBA,ENG
Company :Aspect Imaging LTD., Shoam ,Israel
The photonic microsphere based sensor of specific antibodies PAWEŁ WITYK,1 PAULINA LISTEWNIK,2 AND MAŁGORZATA SZCZERSKA2
1 Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland
2 Department of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, Narutowicza Street 11/12, 80-233 Gdańsk, Poland
Investigation of the hypercapnial effect on cerebral blood flow using imaging photoplethysmography Maxim A. Volynsky, 1,2
Oleg V. Mamontov, 1,3
Anastasiia V. Osipchuk, 4
Valery V. Zaytsev, 1,3
Alexey Y. Sokolov, 4,5
Alexei A. Kamshilin 1,3
1 Institute of Automation and Control Processes of the Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia;
2 ITMO University, Saint Petersburg, Russia;
3 Almazov National Medical Research Centre, Saint Petersburg, Russia;
4 Valdman Institute of Pharmacology, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia;
5 Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint Petersburg, Russia
Studies of the fluorescence kinetics of indocyanine green in nanoscale structures depending on the bioenvironment in vivo Farrakhova D.S.1, Maklygina Yu.S.1, Romanishkin I.D.1, Ryabova A.V.1,2, Yakovlev D.V.1,3, Bezdetnaya L.4,5, Loschenov V.B.1,3
1. Prokhorov General Physics Institute of the Russian Academy of Science, 119991 Moscow, Russia;
2. National Research Nuclear University “MEPhI, 115409 Moscow, Russia;
3. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, 117997 Moscow, Russia;
4. Centre de Recherche en Automatique de Nancy, CNRS, Université de Lorraine, 54519 Vandoeuvre-lès-Nancy, France;
5. Institut de Cancérologie de Lorraine, 54519 Vandoeuvre-lès-Nancy, France;
“Light scattering by a multilayer biological particle” Vera G. Kontsevaya 1, Kirill G. Kulikov 2,
1, Pskov State University, Pskov, Russia, 2 Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia.
Photodynamic inactivation of Escherichia coli bacteria by cationic photosensitizers Gennady A. Meerovich,1,2 Ekaterina V. Akhlyustina,2, Dmitry S. Denisov,3 Ekaterina G. Kholina, 3 Elena A. Makarova, 4 Evgeny A. Lukyanets, 4 Victor B. Loschenov, 1,2 Marina G. Strakhovskaya, 3,5 1 Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia 2 National Research Nuclear University “MEPHI”, Moscow, Russia 3 Lomonosov Moscow State University,Moscow, Russia 4 Organic Intermediates and Dyes Institut, Moscow, Russia 5 Federal Scientific Clinical Center for Specialized Types of Medical Assistance and Medical Technologies for the Federal Medical and Biological Agency, Moscow, Russia
Raman-LIBS for the diagnosis of cancer: From tissue imaging to tumor cells Pengkun Yin1, Zhengying Peng1, Youyuan Chen1, Qingyu Lin2, Yixiang Duan2
1. College of Life Sciences, Sichuan University, Chengdu, Sichuan, People’s Republic of China
2. Research Center of Analytical Instrumentation, School of Mechanical Engineering, Sichuan University, Chengdu, People’s Republic of China
Speckle noise assessment as a method of OCT analysis of brain glioma Polina V. Aleksandrova 1,2,3 Irina N. Dolganova 2,3,4 Kirill I. Zaytsev 1,3,4 Pavel V. Nikitin 4 Anna I. Alekseeva 5 Igor V. Reshetov 6
1 Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia, 2 Institute of Solid State Physics of the Russian Academy of Sciences, Chernogolovka 142432, Russia, 3 Bauman Moscow State Technical University, Moscow 105005, Russia, 4 Institute for Regenerative Medicine, Sechenov University, Moscow 119048, Russia, 5 Research Institute of Human Morphology, Moscow 117418, Russia, 6 Institute for Cluster Oncology, Sechenov University, Moscow 119991, Russia
The study of metabolic properties of mouse hepatocellular carcinoma cell culture using fluorescence lifetime microscopy Ksenia Y. Kandurova,1 Alexander A. Palalov,1 Elena V. Potapova,1 Andrey V. Dunaev, 1 Gerhard Holst,2 Andrey Y. Abramov,1,3 Evgeny A. Zherebtsov,1,4 1 Orel State University, Orel, 302026, Russia 2 PCO AG, Science and Research, Kelheim, 93309, Germany 3 UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK 4 University of Oulu, Oulu, 90014, Finland
UVА LED ANTIVIRAL ACTION ON CORONAVIRUS I. N. Zavestovskaya a, V. A. Guschin b, L. I. Russu b, E. A. Cheshev a, A. L. Koromyslov a, I. M. Tupitsyn a, A. A. Fronya a, c , and M. S. Grigoryeva a, c
a Lebedev Physical Institute, Russian Academy of Sciences, Moscow, 119991 Russia
b National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Moscow, 123098 Russia
c National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, 115409 Russia
Experimental study of ozone-photodynamic effects in malignant growth Evgeniya S. Zhukova,1 Tatiana G. Scherbatyuk,1,2,3 Andrew B. Gapeyev,2,4
1 Nizhny Novgorod research institute for hygiene and occupational pathology, Nizhny Novgorod, Russia; 2 Moscow Region State University, Mytishchi, Moscow Region, Russia; 3 Pushchino State Institute of Natural Science, Pushchino, Russia; 4 Institute of Cell Biophysics of the Russian Academy of Sciences, Pushchino, Moscow Region, Russia
Study of statistical properties the method of analysis of directional couplings based on modeling of phase dynamics Dubinkina Е.S.1, Borovkova E.I.1,2, Karavaev A.S.1,2,3
1Saratov State University, Saratov, Russia
2Department of Innovative Cardiological Information Technology, Institute of Cardiological Research, Saratov State Medical University, Saratov, Russia 4National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia
3Saratov Branch of the Institute of Radio Engineering and Electronics of Russian Academy of Sciences, Saratov, Russia
Optical properties of cholangiocarcinoma tissues in the spectral range of 350-2000 nm under photothermal therapy with gold nanorods Vadim D. Genin,1,2, Alla B. Bucharskay,3, Elina A. Genina,1,2, Georgy S. Terentyuk,3, Nikolai G. Khlebtsov,4, Valery V. Tuchin,1,2,5, Alexey N. Bashkatov,1,2.
1 Saratov State University, Russia, 2 Tomsk State University, Russia, 3 Saratov State Medical University, Russia, 4 Institute of Biochemistry and Physiology of Plants and Microorganisms of RAS, Russia, 5 Institute for Problems of Precision Mechanics and Control of RAS, Russia
Application of a multimodal method for the study of human skin neoplasms with optical clearing in vivo to increase the effectiveness of PDT. I.A. Serebryakova 1.2, Yu.I. Surkov 1,2, E.A. Genina 1,2, E.N. Lazareva 1.2, Y.K. Kuzinova 3, O. M.Konopatskova 3, A.N. Bashkatov 1.2, V.V. Tuchin 1,2,4
1 Saratov National Research State University named after N.G. Chernyshevsky
2 National Research Tomsk State University
3 Saratov State Medical University named after V.I.
Razumovsky Ministry of Health of Russia
4 Institute for Problems of Precision Mechanics and Control, RAS
In vivo OCT investigation of chemical enhance of the rat skin optical clearing by fructose solutions Daria K. Tuchina,1,2 Alexey N. Bashkatov,1,2 Nikita A. Navolokin,1,3 Valery V. Tuchin1,2,4
1Saratov State University, Saratov, Russia; 2National Research Tomsk State University, Tomsk, Russia; 3Saratov State Medical University, Saratov, Russia; 4Institute of Precision Mechanics and Control RAS, Saratov, Russia
Optical clearing of skin by CT and MRI agents in a wide wavelength range Nikita S. Chikalkin1, Daria K. Tuchina,1,2,3 Natalia A. Shushunova,1
Alexander P. Savitsky,3 Alexei A. Bogdanov, Jr.3,4 Valery V. Tuchin1,2,3,5
1Saratov State University, Saratov, Russia; 2National Research Tomsk State University, Tomsk, Russia; 3Federal Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia; 4University of Massachusetts Medical School, Worcester, MA, USA; 5Institute of Precision Mechanics and Control Institute of the Russian Academy of Sciences, Saratov,
Russia
LED LIGHT SOURCES FOR PDT AND IN VITRO PHOTODYNAMIC STUDIES G.A. Meerovich,1,2 K.G. Linkov,1 A. Nekhoroshev,2 D. Glechik,2 A. Borodkin,1 E.V. Akhlyustina,2 I.P. Angelov,3 V.B. Loschenov,1,2 1 Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia 2 National Research Nuclear University “MEPhI”, Moscow, Russia 3 Institute of Organic Chemistry with Centre of Phytochemistry, Institute of Electronics, Bulgarian Academy of Sciences, Bulgaria
Fiber optic soil vibration sensor and data acquisition system Artem T. Turov,1,2 Yuri A. Konstantinov,2 Maksim E. Belokrylov,2 and Aleksander Yu.Maksimov,2
1 Perm National Research Polytechnic University, Komsomolsky prospekt 29, Perm, Russia 2 Perm Federal Research Centre UB RAS, Lenina 13a, Perm, Russia
Sensitivity and specificity of OCR in OME diagnostics Anait L. Dilenyan, 1,2 Pavel A. Shilyagin,2 Daria D. Smirnova,1 Polina V. Bazan,1 Alexander A. Moiseev,2 Dmitrii A. Terpelov,2 Sergey.Yu. Ksenofontov,2 Alexey A. Novozhilov, 1,2
1 Privolzhsky region medical centre, Nizhny Novgorod, Russia
2 Institute oa applied physics of RAS, Nizhny Novgorod, Russia
Pathological cells determination based on blue autofluorescence Ekaterina O. Bryanskaya,1, Angelina I. Dolgikh,1, Andrey V. Dunaev,1, Andrey Y. Abramov,1,2
1Cell Physiology and Pathology Laboratory, Orel State University, Orel, 302026, Russia;
2Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, UK
Application of the fiber-optic system for intraoperative study of pelvic organs in laparoscopic surgery Nadezhda V. Golubova,1 Nikolai I. Polenov,2 Karina A. Zakuraeva,2 Elena V. Potapova,1 Viktor V. Dremin,1,3 Maria I.Yarmolinskaya,2 Andrey V. Dunaev,1 Igor Yu. Kogan,2 1 Research and Development Center of Biomedical Photonics, Orel State University, Russia 2 FSBSI «The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott», Russia 3 College of Engineering and Physical Sciences, Aston University, United Kingdom
In vivo OCT investigation of chemical enhance of the rat skin optical clearing by fructose solutions Daria K. Tuchina,1,2 Alexey N. Bashkatov,1,2 Nikita A. Navolokin,1,3 Valery V. Tuchin1,2,4
1Saratov State University, Saratov, Russia; 2National Research Tomsk State University, Tomsk, Russia; 3Saratov State Medical University, Saratov, Russia; 4Institute of Precision Mechanics and Control RAS, Saratov, Russia
Microhardness and wear resistance of titanium after laser processing in a graphite environment Koshuro Vladimir Aleksandrovich - Yuri Gagarin State Technical University of Saratov
Osipova Elena Olegovna - Yuri Gagarin State Technical University of Saratov, Russia
Fomina Marina Alekseevna - Yuri Gagarin State Technical University of Saratov, Russia
Fomin Aleksandr Aleksandrovich - Yuri Gagarin State Technical University of Saratov, Russia
5-AMINOLEVULINIC ACID AND HEXYL AMINOLEVULINATE MEDIATED PHOTODYNAMIC DIAGNOSTICS AND THERAPY OF CERVICAL DYSPLASIA AND VULVAR LEUKOPLAKIA K.T. Efendiev1, P.M. Alekseeva 1,2, K.F. Orudzhova3, U.D. Agabekova3, E. K. Slovokhodov4, V.B. Loschеnov1,2 1 Prokhorov General Physics Institute of the Russian Academy of Sciences, ul. Vavilova 38, 119991 Moscow, Russia 2 National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Kashirskoe sh. 31, 115409 Moscow, Russia 3 City Clinical Hospital No. 40, ul. Kasatkina 7, 129301 Moscow, Russia 4 Central Clinical Hospital with Polyclinic, Administrative Department of the President of Russian Federation, ul. Timoshenko Marshala 15, 119359 Moscow, Russia
Microhardness and wear resistance of titanium after laser processing in a graphite environment Koshuro Vladimir Aleksandrovich - Yuri Gagarin State Technical University of Saratov, Russia
Osipova Elena Olegovna - Yuri Gagarin State Technical University of Saratov, Russia
Fomina Marina Alekseevna - Yuri Gagarin State Technical University of Saratov, Russia
Fomin Aleksandr Aleksandrovich - Yuri Gagarin State Technical University of Saratov, Russia
Laser Doppler flowmetry in wearable implementation for the detection of arterial hypertension Yulia I. Loktionova, 1; Maria A. Mikhailova, 1, 2; Andrey I. Korolev, 2; Alexander Yu. Gorshkov, 1; Elena V. Zharkikh, 1; Andrey A. Fedorovich, 2, 3; Evgeny A. Zherebtsov, 1, 4.
1 Research and Development Center of Biomedical Photonics, Orel State University named after I.S. Turgenev, Orel, Russia;
2 National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian Federation, Moscow, Russia;
3 Russian Federation State Research Center, Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia;
4 Optoelectronics and Measurement Techniques, University of Oulu, Oulu, Finland.
Polyacrylamide-based phantoms of human skin for fluorescence optical measurements Valery Shupletsov 1, Margarita Mikenkina 1, Evgeny Zherebtsov 1, 2, Viktor Dremin 1, 3, Alexander Bykov 2, Elena Potapova 1, Andrey Dunaev 1, Igor Meglinski 2, 3
1 Research & Development Center of Biomedical Photonics, Orel State University, Orel, Russia;
2 Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland
3 College of Engineering and Physical Sciences, Aston University, Birmingham, UK
Impact of short term ischemia on dynamics of fluorescence lifetime parameters in skin Valery Shupletsov 1, Olga Stelmashuk 1, Julia Loktionova 1, Igor Kozlov 1, Evgeny Zherebtsov 1, 2.
1 Research & Development Center of Biomedical Photonics, Orel State University, Orel, Russia;
2 Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland
In vivo study on NIR light propagation in the human head Priya Karthikeyana*1, Ulriika Honkaa1, Martti Ilvesmäkia2, Hany Ferdinandoa2,
Vesa Korhonen 1, and Teemu Myllyläa1,2
1University of Oulu, Research Unit of Medical Imaging, Physics and Technology, Oulu, Finland
2University of Oulu, Optoelectronics and Measurement Techniques Unit, Oulu, Finland
NIR spectroscopic effects of irradiation on skin tissue: Comparison Study of Invivo and Ex vivo Priya Karthikeyana*,1, Ulriika Honkaa,1, Jesse Lohelaa,1,4, Kalle Ingeta,4, Hany Ferdinando1,
Sakari S. Karhulaa,4,5, Vesa Korhonena,3,5, Juha Nikkinena,4,5, Teemu Myllyläa,2
1University of Oulu, Research Unit of Medical Imaging, Physics and Technology, Oulu, Finland,
2University of Oulu, Optoelectronics and Measurement Techniques Unit, Oulu, Finland,
3Oulu University Hospital, Department of Diagnostic Radiology, Oulu, Finland,
4Oulu University Hospital, Department of Oncology and Radiotherapy, Oulu, Finland,
eMedical Research Center (MRC), Oulu, Finland
Comparison of the capabilities of spectroscopic and video analysis of fluorescence for the diagnosis of cholangiocellular cancer Dmitry V. Yakovlev,1,2 Dina S. Farrakhova,1 Artem A. Shiryaev,3 Tatiana A. Savelieva,1 Igor V. Reshetov,3 Victor B. Loschenov,1,4 1 Prokhorov General Physics Institute of the Russian Academy of Science, Moscow, Russia 2 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, Moscow, Russia 3 University Clinical Hospital no. 1, Oncology Center, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow, Russia 4 National Research Nuclear University “MEPhI, Moscow, Russia;
PD and PDT of precancerous diseases of the oral cavity and larynx after sublingual administration of 5-ALA P.M. Alekseeva1,2, K.T. Efendiev1,2, A.A. Shiryaev3, M.A. Rusakov3, S.I. Samoilova3, I.V. Reshetov3, V.B. Loschenov1.2
1 Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia
2 National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia
3 Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, University Clinical Hospital No.1, Levshin Institute of Cluster Oncology, Moscow, Russia
A study of illumination spectra to improve contrast imaging of biological tissues Nemov V.1, Prizemin V.1, Goriunov I.1, Kozlov I.1, Seryogina E.1, Mamoshin A.1,2, Chernyakov A.3
1 Orel State university named after I. S. Turgenev, Orel, Russia
2 Orel Regional Clinical Hospital, Orel, Russia
3 SHM R&E Center, RAS, Saint-Petersburg, Russia
Comparison of wearable and bedside laser Doppler flowmetry and fluorescence spectroscopy monitors Elena Zharkikh,1 Yulia Loktionova,1 Denis Drozdov,1 Viktor Dremin,1,2 Victor Sidorov,3 Edik Rafailov,2 Andrey Dunaev,1.
1 Research & Development Center of Biomedical Photonics, Orel State University, Orel, Russia;
2 College of Engineering and Physical Sciences, Aston University, Birmingham, UK;
3 SPE “LAZMA” Ltd., Moscow, Russia.
Fluorescent indices of ornamental plants treated with growth regulators Olesya A. Kalmackaya,1 Vladimir A. Karavaev, 1 Ekaterina I. Gunar, 2
1 Lomonosov Moscow State University, Moscow, Russia
2 Russian State Agrarian University – Moscow Timiryazev Agricultural Academy, Moscow, Russia
Oscillation processes in synuclein-KO mouse skin microcirculation: a pilot study. Kozlov I.O.1, Serov D.A.2, Seryogina E.S.3 Astashev M.E.2 Tankanag A.V.2 Chaprov K.D.4 Lysikova E.A.4 Zherebtsov E.A.3,5 Abramov A.Y.3,6 Dunaev A.V.1,3,
1 R&D Center of Biomedical Photonics, Orel State University, Orel, Russia
2 Institute of Cell Biophysics, Russian Academy of Science, Pushchino, Moscow region, Russia
3 Cell Physiology and Pathology Laboratory, Orel State University, Orel, Russia
4 Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia.
5 Optoelectronics and Measurement Techniques Laboratory, University of Oulu, Oulu, Finland
6 Department of Clinical and Movement Neurosciences, UCL Queen Square Institute
of Neurology, London, UK
Optical analysis of juvenile dentin biomaterials during their manufacture Pavel Е. Timchenko,1, Еlena V. Timchenko,1, Larisa Т. Volova,2, Оleg О. Frolov,1, Mikhail Y. Vlasov,3, Svetlana S. Shipko,1 1 Samara National Research University, Samara, Russia 2 Samara State Medical University, Institute of Experimental Medicine and Biotechnology, Samara, Russia 3 Tissue Bank Research Center, Samara, Russia
Chemometric analysis of the composition of hydroxyapatite after delipidation Pavel Е. Timchenko,1 Elena V. Timchenko,1 Elena V. Pisareva,1 Mikhail Y. Vlasov,2,3 Оleg О. Frolov,1 Larisa Т. Volova,2,3 Ravil Т. Samigullin,1 1 Samara National Reserch University, Samara, Russia 2 Samara Medical University, Samara, Russia 3 "Samara Tissue Bank" Research Center, Samara, Russia