OCT monitoring of skin refractive index by optical clearing ex vivo
Yu.I. Surkov 1.2, I.A. Serebryakova 1.2, A.N. Bashkatov 1.2, E.A. Genina 1.2
1 Saratov National Research State University N.G. Chernyshevsky
2 National Research Tomsk State University
Abstract
In this work, we have implemented a simple method for monitoring the average group refractive index and geometric characteristics of rat skin during its optical clearing (OC) PEG-300 using an optical coherence tomography (OCT). The main advantage of this OCT monitoring method is that it allows you to simultaneously and continuously monitor both the group refractive index averaged over the thickness and the geometric thickness without interrupting the natural course of the OC process and without repositioning the sample, which has a positive effect on the measurement accuracy. It has been shown that the method can also be used to assess the content of an optical clarifying agent (OCA) and water in the skin.
Speaker
Surkov Yuriy Igorevich
SSU
Russia
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