Ex vivo study of glycerol and glucose perfusion-kinetics in cat ovaries with serous carcinoma and leiomyosarcoma
Alexey A. Selifonov,1, Andrey S. Rykhlov,2, Valery V. Tuchin3,4,5
1Education and Research Institute of Nanostructures and Biosystems,
Saratov State University, Saratov 410012, Russia
2Clinic "Veterinary Hospital" , Saratov State University of Genetics, Biotechnology and Engineering named after N.I. Vavilov, Saratov 410012, Russia
3Science Medical Center, Saratov State University, Saratov 410012, Russia
4Laboratory of laser molecular imaging and machine learning, Tomsk State University, Tomsk 634050, Russia
5Institute of Precision Mechanics and Control, FRC “Saratov Scientific Centre of the Russian Academy of Sciences,” Saratov 410028, Russia
Abstract
Ovarian cancer is one of the leading causes of death for women worldwide. More than 70% of cancer cases are only diagnosed in advanced stages. If ovarian cancer is detected in the initial stages, then a complete remission is 94%, while the detection of a tumor in the later stages reduces the likelihood of survival to 45%. Despite advances in modern medicine, the five-year survival rate for patients with this diagnosis has not increased much over the past half century. Modern research on the problem of early diagnosis and effective treatment of cancer of the reproductive system combines the achievements of surgery, research on genomics, precision therapy, etc. Research on ovarian cancer is relevant, allowing in the future to improve the identification of the pathological process at an earlier time. When using optical systems in clinical medical practice, strong light scattering of biological tissues does not allow radiation to pass into the deep layers and obtain ultra-precise images. One approach to solving this problem can be the optical clearing method, which is implemented using optical clearing agents, in particular glycerol and glucose. The paper presents the results of their influence on the efficiency of optical clearing of the ovaries of cats with serous carcinoma and leiomyosarcoma, as well as differentia
https://sfmconference.org/sfm/sfm23/registration/#tion in their perfusion-kinetic properties.
This work has been supported by the Russian Science Foundation Grant No. 22-75-00021.
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Alexey Selifonov
SSU
Russia
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