Non-invasive optical sensor for liver state accessment
Elina K. Nepomnyashchaya, 1 Ilya N. Kolokolnikov, 1 Ekaterina А. Savchenko, 1
Peter the Great St. Petersburg Polytechnic University, Saint Petersburg, Russia
Abstract
One of the topical issues in modern medicine is the assessment of liver state. Liver diseases is one of the most common chronic pathologies both in Russia and in most other developed countries. With proper control of the disease, associated liver damage can be minimized. The paper proposes a laboratory model of a combined optical sensor and the corresponding software for non-invasive monitoring of the liver functional reserves. The sensor is based on dynamic light scattering and pulse densitometry methods. Dynamic light scattering is used to determine blood flow velocity in microcapillaries and analyze microvasculature pathologies. Due to the close correspondence between capillaries state and the state of the excretory organs, it is an important parameter in liver diagnostics. The pulse densitometry is used to detect the excretory function of liver. We used medical dye injected in blood and detected the dye elimination curve. Due to correct dye choice, it was eliminated only by liver. So, the elimination speed is corresponded mainly to the liver function and shous it functional reserves. Using the developed measurement technique, we analyzed the liver function of several groups of patients in surgical department of hospitals. The obtained data was compared with results received by several other reliable methods regularly applied in medicine. The results of the work showed a high correspondence of the data on liver state and medical prognoses on patients’ treatment.
Speaker
Elina Nepomnyashchaya
Peter the Great St.Petersburg Polytechnic University
Russia
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