Determination of methotrexate in micromolar concentrations using glasses with a modified nanostars surface.
Evtifeev Denis.O.1, Zozulya Alexander.S.1, Demishkivich Elizaveta.A. 1,2, Kundalevich Аnna.А 1,2, Zubin Аndrey.Y. 1
Samusev Ilya.G. 1
1. Immanuel Kant Baltic Federal University, Kaliningrad, Russia
2. Saratov National Research State University named after N.G. Chernyshevskogo, Saratov, Russia
Abstract
Methotrexate is a drug used in the treatment of rheumatoid arthritis. At high concentrations in human blood, it has a toxic effect on its body, so the qualitative and quantitative determination ofthe oncentration of methotrexate in the human body is animportant task
As part of this study, the results of Raman scattering of methotrexate light using gold nanostars on APTES-modified glasses were obtained.
The spectra of methotrexate obtained on APTES-modified glasses have a high intensity, which indicates the presence of amplification of the cattle signal, which, in turn, makes it possible to detect lower concentrations of methotrexate, up to micromolar, which are contained in human blood.
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Denis
Immanuel Kant Baltic Federal University
Russia
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