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Ultrasonic modes to improve the optical clearing of the skin ex vivo

Daria K. Tuchina,1,2 Alexey N. Bashkatov,1,2 Nikita A. Navolokin,3 Valery V. Tuchin1,2,4
1 Saratov State University, Saratov, Russia
2 Tomsk State University, Tomsk, Russia
3 Saratov State Medical University, Saratov, Russia
4 Institute of Precision Mechanics and Control RAS, Saratov, Russia


The experimental study of ultrasonic modes was performed for ex vivo skin samples of white Wistar rats. The ultrasound was provided by a Dynatron 125 US system (Dynatronics, USA) after applying an optical clearing agent (OCA), aqueous-alcohol-fructose (20%-30%-50%) solution, to the sample surface. Three different ultrasonic modes were used to found the most effective and fastest OCA delivery rate. The optical coherence tomography system, Spectral Radar OCT System OCP930SR 022 (Thorlabs Inc., USA) with a wavelength of 930 nm, was used for obtaining the quantitative data for effectiveness and rate of skin optical clearing. The best mode had a frequency of 3 MHz and a power of 1.5 W in continuous mode for 3 minutes.


Daria Tuchina
Saratov State University; Tomsk State University


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