Experimental Comparison of Photodynamic Therapy Efficacy Using Indocyanine Green and Photosens in a Colorectal Cancer Model
Alena K. Shatenova1, Natalia A. Shushunova2, Vadim D. Genin1, Alla B. Bucharskaya2, Elina A. Genina1;
1Saratov State University, Saratov, Russia;
2Saratov State Medical University, Saratov, Russia
Abstract
Indocyanine green is widely used in medicine as a fluorescent dye for assessing cardiac function and vascular perfusion. This study compared the efficacy of photodynamic therapy (PDT) with two photosensitizers: indocyanine green (ICG, activation at 808 nm) and Photosens (PS, activation at 662 nm). The experiment was performed on Balb/c mice bearing a colorectal cancer model. PDT outcomes were evaluated by tumor volume dynamics over three weeks and histology. PDT with ICG was accompanied by a temperature increase above 48°C and resulted in complete tumor regression in both mice, with no tumor cells detected in histological sections. After PDT with Photosens, tumors continued to grow, with necrosis comprising only 20–30% of the volume. ICG demonstrated significantly higher efficacy than Photosens for PDT of colorectal cancer in mice. The work was supported by RSF grant 23-14-00287-P.
Keywords: photodynamic therapy, indocyanine green, Photosens, colorectal cancer.
Speaker
Alena K. Shatenova
Saratov State University, Saratov, Russia
Russia
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