Advances in Monte Carlo simulations for various optical diagnostics modalities
Mikhail Kirillin, A.V. Gaponov-Grekhov Institute of Applied Physics RAS, Nizhny Novgorod, Russia
Abstract
Advances in modern biomedical diagnostic techniques require simulation of signal formation in such systems that accurately account for features of light interaction with biological tissues which commonly exhibit complex morphology. The challenge is traditionally overcome by employment of statistical Monte Carlo technique which is based on simulation of random photon trajectories based on predefined geometrical and optical properties. In this paper an overview of applications of Monte Carlo simulations to imitate signal and image formation in different optical diagnostics modalities is provided. The paper discusses the aspects of simulations of spectral and fluorescence diagnostics techniques as well as coherence-based techniques such as optical coherence tomography and laser speckle contrast imaging. Comparison with other models and experimental measurements is provided.
The study is supported by the Russian Science Foundation (project 24-15-00175),
https://rscf.ru/en/project/24-15-00175/.
Speaker
Mikhail Kirillin
A.V. Gaponov-Grekhov Institute of Applied Physics RAS
Russian
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