Laser-optical evaluation of blood microrheology preconditioning effect in vitro
Alexander V. Priezzhev1, Matvei K. Maksimov1, Danila A. Umerenkov1, Pavel A. Moldon1,
Alexei V. Muravyov2, Andrei E. Lugovtsov1; Lomonosov Moscow State University, Moscow, Russia; Ushinsky Yaroslavl State Pedagogical University, Yaroslavl, Russia
Abstract
Impaired blood flow and oxygen delivery to tissues and organs is a global medical problem.
In this paper, we will discuss new technologies for targeted blood conditioning to improve its microrheological properties. We propose a set of models for studying various aspects of preconditioning and explore ways of their practical application. Emphasis will be placed on increasing erythrocytes deformability (ED) changes in which relative to the norm are characteristic of many socially significant diseases. Changes in ED also occur during blood storage outside the body, particularly for transfusions to sick individuals, suffering from a number of diseases and injuries. Normalization of ED can significantly improve the effectiveness of treatments and ensure a higher level of adaptation to ischemia, hypoxia, muscle fatigue, stress, and other pathological factors. Blood conditioning refers to exposing a certain volume of blood to specific factors in vitro, which results in targeted changes in ED. This results in improved blood flow and microvascular perfusion of all tissues and organs. Several approaches to blood conditioning will be considered: exposing a volume of erythrocyte suspension (whole blood and/or red blood cell mass) in vitro to measured shear stresses below the level of cell hemolysis, exposure to certain pharmacological agents and gasotransmitters, and irradiation with low-intensity visible or NIR light.
Speaker
Alexander Priezzhev
Lomonosov Moscow State University
Russia
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