Laser vaccine adjuvants in mice: laser sources and biological mechanisms
Anna Khokhlova1, Yury Saenko1, Anastasiia Spiridonova1, Dmitry Korobko1, Pavel Itrin1, Maxime Pribylov1, Aleksei Abanin1, Sergei Sokolovski2, Edik Rafailov2 and Andrei Fotiadi1,3; 1S.P. Kapitsa Scientific Technological Research Institute, Ulyanovsk State University, Ulyanovsk, Russia; 2Optoelectronics and Biomedical Photonics Group, School of Engineering and Applied Science, Aston University, Birmingham, UK; 3Electromagnetism and Telecommunication Department, University of Mons, Mons, Belgium.
Abstract
The use of laser irradiation as an adjuvant for intradermal vaccination has gained considerable attention over the past decade. A substantial body of evidence has accumulated regarding the local biological effects of laser irradiation; however, the majority of studies remain at the preclinical stage. Most in vivo investigations have been conducted using laboratory mice, which represent the standard experimental model in immunology for vaccine evaluation and provide a convenient platform for preclinical research.
Here, we present a systematic analysis of studies investigating the effects of laser irradiation in mice at both the local level (i.e., at the site of skin irradiation) and the systemic level. This analysis is expected to help identify existing gaps in the understanding of the underlying biological mechanisms, determine the most effective laser irradiation parameters for activation of the immune response, and support the development of more effective laser irradiation-based vaccine adjuvants.
This work was funded by the Ministry of Science and Higher Education of the Russian Federation (project FEUF-2026-0005, biological mechanisms review) and Russian Science Foundation (project number 23-79-30017, laser sources review).
Speaker
Anna Khokhlova
S.P. Kapitsa Scientific Technological Research Institute, Ulyanovsk State University, Ulyanovsk
Russia
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