Assessment of developmental stages of infantile hemangiomas using hyperspectral imaging
Valery V. Shupletsov1, Ilya A. Goryunov1, Elena V. Potapova1, Ivan P. Zhurilo2, Andrey V. Dunaev1, Victor V. Dremin1;
1Orel State University named after I.S. Turgenev, Orel, Russia
2Tochka Opory Medical Center, Orel, Russia
Abstract
Infantile hemangiomas exhibit age-dependent phases of proliferation, stabilization, and involution, while objective assessment of their functional state remains limited in clinical practice. This study evaluated hyperspectral imaging (HSI) for differentiating developmental stages of infantile hemangiomas using blood volume fraction and tissue oxygen saturation.
Forty-two infants with hemangiomas of different locations and clinical types were examined. The developed HSI system included a broadband light source, a fiber-optic ring illuminator, and a hyperspectral camera operating in the 400–1000 nm range. Neural-network-based processing was used to generate diagnostic maps of blood volume fraction and tissue oxygen saturation. According to lesion age, the data were divided into three periods: 0–180 days (progression), 180–300 days (stabilization), and more than 300 days (regression). Mean values, standard deviations, and ±3 SD ranges were calculated for each period. A progression index was introduced as the ratio of an individual diagnostic value to the mean value for the corresponding period.
Interperiod analysis revealed distinct distributions of diagnostic parameters across the three stages. Mean tissue oxygen saturation was approximately 95%, 96%, and 98% for the progression, stabilization, and regression periods, respectively. Isolated values outside the ±3 SD range indicated pronounced individual deviations in hemodynamic status. A progression index below 1 reflected reduced diagnostic parameters relative to the period-specific mean, whereas values above 1 indicated higher oxygenation and a possible transition toward regression.
These findings support HSI as a promising tool for stage assessment and personalized monitoring of infantile hemangiomas.
This work was supported by the Russian Science Foundation, Grant No. 25-25-00482
Speaker
Valery Shupletsov
Orel State University named after I.S. Turgenev, Orel, Russia
Russia
Discussion
Ask question
