Effect of surface modification of non‑woven materials on their adsorption and optical properties

Abstract

The regeneration and restoration of bone tissue in cases of defects caused by injuries, tumoral and inflammatory processes remains one of the pressing tasks of modern regenerative medicine. At present, the main solution remains permanent metal implants, primarily titanium ones; however, their inability to biodegrade, the mismatch between their elastic modulus and that of native bone, and insufficient osteointegration limit their use. At the same time, a promising alternative is the concept of tissue engineering, which is based on the use of biodegradable three‑dimensional porous scaffolds — scaffolds that temporarily replace damaged tissue and provide a favorable microenvironment for cell adhesion, proliferation, and differentiation. The effectiveness of regeneration is largely determined by the adsorption properties of the scaffold surface, since it is the adsorbed protein layer that mediates the subsequent cellular response. Widely used hydrophobic polyesters (polycaprolactone, polylactide) have a limited ability to adsorb proteins, which reduces their biological activity. In this regard, interest is growing in more hydrophilic polymer bases, in particular polyacrylonitrile, as well as in methods of targeted surface modification using biocompatible organic and inorganic particles — nanocellulose and calcium carbonate. Studying the effect of such a modification on protein adsorption and release using spectrophotometry, as an informative and accessible method, is of undeniable scientific and practical significance.

Speaker

Victoria Isaeva
Saratov State University
Russia

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