Adaptive Peptides as Promising Gas-Sensing Materials: Insights from Molecular Modeling
Alexander A. Petrunin1, Olga E. Glukhova1,2; 1Saratov State University, Saratov, Russia; 2I.M. Sechenov First Moscow State Medical University
Abstract
link.springer.com
Magnetic Liposomes for Remote Controlled High-Molecular Drugs Release under a Low-Frequency Non-Heating Magnetic Field
K Yu Vlasova, S Ch Vanzarakshaeva, MM Veselov, IM Le-Deygen, AV Petrunin, AN Prusov, AB Shuklinov, Yu I Golovin, AV Kabanov, NL Klyachko
Moscow University Chemistry Bulletin 75 (4), 232-237, 2020
Magnetic anionic liposomes (MALip) conjugated with magnetite magnetic nanoparticles (MNPs) are developed for the controlled release of a protease inhibitor (BBI) under exposure to a low-frequency nonheating magnetic field (LF AMF). It is shown that an increase of up to 35% of the protein release rate occurred when the MALip are exposed to the LF AMF (frequency 110 Hz, intensity 75–150 kA/m) for 5–15 min. The research provides prospects for the development of remotely controlled protein release from liposomes.
Просмотреть на сайте link.springer.com
[PDF] unc.edu
Цитируется: 1
Похожие статьи
Все версии статьи (8)
Adaptive peptide molecule as the promising highly-efficient gas-sensor material: in silico study
Alexander A Petrunin, Maxim K Rabchinskii, Victor V Sysoev, Olga E Glukhova
Sensors 23 (13), 5780, 2023
Gas sensors are currently employed in various applications in fields such as medicine, ecology, and food processing, and serve as monitoring tools for the protection of human health, safety, and quality of life. Herein, we discuss a promising direction in the research and development of gas sensors based on peptides—biomolecules with high selectivity and sensitivity to various gases. Thanks to the technique developed in this work, which uses a framework based on the density-functional tight-binding theory (DFTB), the most probable adsorption centers were identified and used to describe the interaction of some analyte molecules with peptides. The DFTB method revealed that the physical adsorption of acetone, ammonium, benzene, ethanol, hexane, methanol, toluene, and trinitrotoluene had a binding energy in the range from −0.28 eV to −1.46 eV. It was found that peptides may adapt to the approaching analyte by changing their volume up to a maximum value of approx. 13%, in order to confine electron clouds around the adsorbed molecule. Based on the results obtained, the prospects for using the proposed peptide configurations in gas sensor devices are good.
Speaker
Alexander A. Petrunin
Saratov State University
Russia
Discussion
Ask question
