Low-coherence Biophotonic Imaging for the Brain

Abstract

This talk will highlight our recent advances in using low-coherence light to explore the brain. We will focus on two scenarios: (1) intraoperative assessment of brain cancer infiltration in patients, and (2) real-time imaging of dynamic neural activities in freely-behaving rodents. In the first scenario (clinical-oriented), we developed a noninvasive, color-coded quantitative OCT (qOCT) technology that provides neurosurgeons with direct, real-time visual cues to maximize cancer resection while preserving healthy tissue. Results from more than 60 patients show excellent specificity and sensitivity (94% or better). In the second scenario (basic research), we created the first all-fiber-optic, head-mounted, ultracompact (~2.4 mm diameter) and ultralight (<1 g) two-photon fiberscopy platform, enabling high-resolution, large–field-of-view (~500 μm) imaging of neuronal activity in freely-walking/rotating mice. Detailed imaging results will be shared during the seminar, and, if time permits, we will also discuss other translational applications of these technologies for noninvasive, in vivo optical histology.

Speaker

Xingde Li
Johns Hopkins University
USA

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