1 T MRI and biophotonics methods: synergy of approaches in biomedical research.

Abstract

The report highlights the integration of 1 T MRI and biophotonics for advancing biomedical research. These complementary approaches enable comprehensive study of dynamic biological processes: MRI delivers tissue level spatial visualization, while biophotonics offers high sensitivity to molecular and cellular changes.
A key focus is optical clearing (OC), which enhances the effectiveness of both methods. The work also covers genetically encoded sensors (based on colored proteins) combined with dCas9 for targeted tumor detection, as well as polymeric systems encapsulating indocyanine green (ICG) and gadolinium citrate (Gd). Investigating polymer resorption and agent release kinetics helps assess MRI contrast duration and photoactive label efficiency.
1 T MRI tracks tissue remodeling, vascularization, and scaffold integration, whereas biophotonic methods detail cellular infiltration and expression of inflammation and proliferation markers. Additionally, laser induced nanoparticles for wound healing are discussed: laser exposure generates nanoparticles in the injury zone, potentially modulating cellular activity and accelerating regeneration. Biophotonics quantifies their effects, while 1 T MRI visualizes structural tissue changes.
The synergy of these modalities improves research accuracy and enables development of multimodal protocols. Such approaches hold particular promise for preclinical studies requiring detailed characterization across spatiotemporal scales.

Speaker

Zherdeva Victoria
RC of Biotechnology RAS
Russia

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