Cancer diagnostics based on the “cancer quencher”: experimental and clinical data (a problem-setting report for the round-table discussion)
Elena V. Naumova1, Ilya V. Volodyaev2; 1 Rzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia; 2 Lomonosov Moscow State University, Moscow, Russia
Abstract
"Cancer quencher" is the first blood tumor marker claimed more than 25 years before alpha-fetoprotein. It was detected by its ability to quench the intrinsic ultra-weak luminescence of blood and other systems in the middle ultraviolet range (mitogenetic radiation). The developed cancer diagnostic method was extensively tested in the leading oncology clinics of the USSR and demonstrated high sensitivity and specificity (both >95%), which is significantly higher than that of modern blood tumor markers. The best Soviet oncologists of that time (N.N. Petrov et al.) advocated for the further development and clinical implementation of the method. However, shortly after the August 1948 Session of the Lenin All-Union Academy of Agricultural Sciences (VASKhNIL), research in this direction was halted, and access to publications was restricted.
The report presents a brief summary of the results of original works of the 1930s–1940s on the physical, chemical, and biomedical properties of this tumor marker, with an emphasis on paradoxical experimental data, the explanation of which remains highly relevant to this day. Additionally, a number of later experimental works that the authors consider related to the subject are presented.
Speaker
Elena V.Naumova
Rzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
Russia
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