Studying the composition of urine thermal decomposition products of patients with prostate tumors (pilot study) by high-resolution terahertz gas spectroscopy
V.L.Vaks1,2, V.A.Atduev3,4, A.V.Maslennikova1,4, E.G.Domracheva1,2, M.B.Chernyaeva1,2, V.A.Anfertev2. K.A.Atduev3, M.A.Rodionov1,2, M.F.Pereira5
1Lobachevsky State University, Nizhny Novgorod, Russia; 2Institute for Physics of Microstructures of RAS, Nizhny Novgorod, Russia; 3Privolzhsky District Medical Center of the Federal Medical and Biological Agency of Russia, Nizhny Novgorod,Russia; 4Privolzhsky Research Medical University, Nizhny Novgorod, Russia; 5Khalifa University of Science and Technology, Abu Dhabi, UAE
Abstract
Prostate cancer (PC) is one of the most common malignant tumors in men. Despite significant advances in its diagnosis and treatment, the challenge of early detection remains significant, making the search for non-invasive and reliable biomarkers for this condition highly relevant.
Identification of specific thermal decomposition products of urine of prostate tumors patients (24 patients with prostate cancer and 14 patients with benign prostatic hyperplasia (BPH)) was carried out with using THz non-stationary high-resolution spectroscopy.
A large number of secondary metabolites such as methylbutyronitrile, pentadiene nitrile, ethynyl benzonitrile and methyl mercaptan were detected in samples of patients with PC (compared with urine samples of patients with BPH). The appearance of sulfur-containing compounds such as sulfur dioxide, hydrogen sulfide, and methyl mercaptan may be due to the thermal decomposition of sulfur-containing amino acids (methionine, cysteine, and cystine). In addition, a number of substances were identified that were found only in urine samples from prostate cancer patients, including representatives of the aldehyde class (benzaldehyde, glycolaldehyde, and malone dialdehyde). The increased content of aldehydes, in particular glycolaldehyde, in samples from cancer patients may be associated with the breakdown of sugars (glucose etc.).
The analysis of secondary metabolites in the urine of patients with PC and BPH revealed differences in the composition and concentration of substances. These differences could serve as a basis for developing non-invasive urinary markers for PC, offering a promising diagnostic method.
Speaker
Vladimir Vaks
IPM RAS
Russian Federation
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