Analysis systems in biophotonics using the example of real research

Abstract

Currently, the field of optical instrumentation is rapidly developing, which is associated with significant improvements not only in the quality of the used components but also in the production technological processes themselves. There is also a trend towards miniaturization in this area, driven by enhanced optical properties of components, reduced sizes of electronic elements, and improved quality of device layout. This enables the design of analytical optical equipment intended for solving a wide range of tasks in photonics.

This work presents a review of equipment for the visualization, analysis, and measurement of signals in biophotonic systems, as well as methods for exciting these signals. Additionally, we conducted an analysis of modern trends in the highly promising research area dedicated to the interaction of light with biological tissues and fluids.

Special attention in the work is paid to analytical equipment for studying inelastic light scattering by biological tissues. This class includes highly sensitive spectral and spectrophotometric systems of the visible and near-infrared ranges, as well as means of excitation (probing) radiation—single-frequency laser sources, ultrafast lasers, and broadband sources for optical coherence tomography. The presented devices are designed to study fluorescence, Raman (Stokes and anti-Stokes) scattering, surface-enhanced Raman scattering, multiphoton absorption, and other nonlinear effects.

The work also includes an analysis of modern optical imaging systems, among which confocal microscopes, multiphoton microscopes, and microscopes with fluorescence lifetime imaging capability can be highlighted. Systems of the latter type require highly precise time-correlated systems with optical detectors of increased sensitivity, which is also shown in the review.

The work addresses issues of prototyping optical systems for biophotonics. We provided a review of modern, accessible, and high-quality optomechanical components and optics for prototyping analytical instrumentation.

Finally we presented the considerations on the potential use of quantum technologies in applied tasks of biophotonics. This is a new direction that, in the future, alongside classical analytical methods, could play a significant role in the fight against socially significant diseases.

In conclusion, modern biophotonics is actively developing due to the improvement of equipment for the visualization, analysis, and generation of optical signals. Particular progress is observed in the area of inelastic light scattering methods and advanced microscopy systems, which expands the possibilities for studying biological tissues and fluids. The availability of high-quality components for prototyping plays an important role in this, accelerating the development of new devices. The integration of quantum technologies appears to be a promising direction, which in the future could significantly enhance the accuracy of diagnostics and the effectiveness of the fight against diseases.

Speaker

Anton
LLC INSCIENCE SOLUTIONS
Russia

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