In vivo study of statistics of polarization laser speckle fields from human skin during immersion optical clearing with glucose solutions
Anton A. Kharchenko1, Polina A. Timoshina1,2, Valery V. Tuchin1,2,3;
1Saratov State University, Saratov, Russia; 2Tomsk State University, Tomsk, Russia; 3Institute of Precision Mechanics and Control, FRC "Saratov Scientific Center of the Russian Academy of Sciences", Saratov, Russia
Abstract
One of the modern research areas is the study of the effect of glucose on biological tissues. External glucose intake can affect the skin structure.
The aim of our study is to investigate the effect of glucose solutions of different concentrations on the epidermis and dermis. Our task is to calculate the statistics of laser polarized speckles of the 1st and 2nd order. To estimate the time of epidermis dehydration. The degree of clearing is displayed by the probability distribution function. The change in the structure of biological tissues is well described by the obtained autocorrelation function.
The nonlinearity of the clearing process caused by dehydration and erythema, which change the polarization and depolarization of the reflected radiation, was studied. It was found that erythema polarizes light to some extent due to the influx of fluid and the "destruction" of long-range (depolarized) photons caused by increased blood absorption.
Speaker
Anton A. Kharchenko
Saratov state University
Russia
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