Brain photobiomodulation device designed for MRI compatibility
Sergey V. Popov1, Egor V. Ilyukov1, Ivan V. Fedosov1, Oksana V. Semyachkina-Glushkovskaya2; 1Institute of Physics, Saratov State University, Saratov, Russia, 2Department of Biology, Saratov State University, Saratov, Russia
Abstract
Brain photobiomodulation (PBM) represents a promising avenue in neuroscience, providing new possibilities for modulating neuronal activity without requiring invasive procedures. Of special interest is its potential application in treating neurodegenerative disorders, including Alzheimer's disease, where PBM may aid in restoring cognitive functions, enhancing metabolic activity within nervous tissue, and decelerating neurodegeneration progression. Investigating PBM mechanisms and clinical uses necessitates integrating this technique with high-precision neuroimaging methods, particularly magnetic resonance imaging (MRI). However, employing conventional PBM devices inside the MRI environment involves technical challenges: the strong magnetic field and radiofrequency interference can impair electronic components’ operation, decrease system reliability, and alter stimulation parameters. Consequently, specialized solutions that are resistant to MRI environmental effects are essential. In this study, a PBM device was developed that is entirely structurally compatible with MRI study conditions. The designed system consists of a flexible LED matrix, a shielded control module, and a switching unit, all connected by a flat cable containing minimal metal parts. Control signals are transmitted via a 10-meter fiber-optic cable, effectively eliminating the influence of MRI electromagnetic fields on control electronics. Power is supplied by an autonomous battery, ensuring complete independence from external power sources within the scanner vicinity. The programmable control module enables the setting of a broad range of stimulation parameters tailored to specific research or therapeutic objectives.
Experimental evaluations demonstrated that the device maintains stability under the high magnetic fields and radiofrequency radiation typical of MRI scanning. Additionally, MRI image quality was not compromised, no artifacts appeared, and PBM parameters remained accurately within predetermined values without deviations. The device’s main advantage is its full electromagnetic compatibility with MRI equipment, allowing PBM to be administered simultaneously with scanning without affecting imaging performance. Therefore, this development creates new opportunities for real-time comprehensive investigation of PBM’s neurophysiological effects, as well as for forward-looking diagnostic and therapeutic protocols designed to slow neurodegenerative disease progression, such as Alzheimer's disease.
This work was supported by the Russian Science Foundation (Grant No. 24-45-00010).
Speaker
Sergey Popov
Saratov State University
Russia
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