Speckle contrast imaging of the vascular system in the context of the development of an experimental model of type 1 diabetes
Mikhail V. Syrov1, Alexander D. Kovalev1, Polina A. Timoshina1, 2, Valery V. Tuchin1, 2, 3;
1 -Saratov State University, Saratov, Russia;
2 -Tomsk State University, Tomsk, Russia;
3 - Institute of Precision Mechanics and Control Science, Russia
Abstract
Type 1 diabetes mellitus is accompanied by serious microcirculation disorders leading to angiopathy, retinopathy, nephropathy and other complications. In recent years, speckle contrast imaging has attracted the interest of researchers, which makes it possible to noninvasively assess the state of the microcirculatory bed.
To solve this problem, optical brightening agents are used, which temporarily reduce light scattering. Their combination with speckle contrast imaging opens up new possibilities for studying microcirculatory changes in experimental type 1 diabetes, improving image quality and allowing the analysis of vascular changes in the early stages of the disease.
This study was supported by the grant from the Russian Sciece Foundation № 23-14-00287
Speaker
Mikhail Syrov
Saratov State University
Russia
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