Surgery guidance with biophotonics and its clinical translation

Abstract

Fluorescence-guided laser surgery has emerged as a powerful tool for enhancing precision and safety in minimally invasive procedures. This talk explores recent advances in optical navigation for surgical applications, with a focus on novel contrasts (mainly, endogenous fluorophores) and their clinical translation. Namely, in the recent years, we've implemented several optical spectroscopy-based features for laser surgery in urology. The first system is the tissue sensor for laser lithotripsy, allowing real time differentiation between urinary stones and surrounding tissue, which improves stone fragmentation and minimizes collateral damage. The second advancement is the bladder cancer tumor margin delineation based on multimodal diffuse reflectance and fluorescence spectroscopy approach, enabling complete resection and reducing recurrence rates. Finally, all-optical temperature monitoring during surgery has been developed which prevents excessive tissue heating and improving procedural safety. Altogether, the developed optical sensors pave the way for more efficient and safe laser surgery in urology.

Speaker

Evgeny Shirshin
Moscow State University
Russia

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