The development of an advanced hydroxyapatite biomaterial with antibacterial properties for regenerative medicine application
Anastasia A. Kabanova1,2, Anastasia E.Rezvanova3, Boris S.Kudryashov3, Ekaterina A. Nosova4, Olga Y. Kochetkova5; 1Samara State Medical University, Samara, Russia, 2Samara State Technical University, Samara, Russia, 3Institute of Strength Physics and Materials Science of the Siberian Branch of the Russian Academy of Sciences, Tomsk, Russia, 4Samara University, Samara, Russia, 5Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia
Abstract
The presence of multidrug-resistant microorganisms poses a significant worldwide challenge for humanity due to the excessive usage of antibiotics in healthcare and surgical interventions, especially during implantation procedures. Infections that occur around implants are caused by bacteria that attach to the surfaces of the implants and eventually develop biofilms there. Currently, in implantology, the creation of antibacterial materials or coatings for implants is one of the most promising strategies. Hydroxyapatite (HA) is inorganic component of hard tissues is widely used in various medical procedures due to excellent biocompatibility, osteoconductivity, non-toxic nature and thermal stability. Synthetic and natural hydroxyapatite demonstrates any antibacterial properties. The main goal of our study is to synthesize and analyze antibacterial properties and cytotoxicity of selenium-substituted synthetic and natural HA powders. The natural hydroxyapatite was extracted from spongy and compact bovine bone tissue through a precipitation method. Characterization of the HA samples was conducted using scanning electron microscopy, X-ray diffraction, and infrared spectroscopy. It was found that selenium could replace phosphorus without affecting the crystal lattice of HA. The antibacterial and antifungal properties of the HA, along with its cytotoxicity, were assessed. The results indicated that the most effective and non-toxic variant was the selenium-substituted HA derived from compact bone tissue. The work was performed within the Government Assignment of Work for the ISPMS SB RAS (Project FWRW-2022-0002).
Speaker
Kabanova Anastasia
Samara State Medical University
Russia
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