The prospects of optical coherence tomography angiography for monitoring microcirculatory disorders in critically ill patients
Anton A. Plekhanov1, Elena B. Kiseleva1, Sergey V. Panfilov2, Alexander A. Moiseev3, Natalia V. Zarechnova2, Marina A. Sirotkina1, Sergey V. Gamayunov2, Grigory V. Gelikonov3, Evgeniy V. Grigoryev4, Natalia D. Gladkova1; 1Privolzhsky Research Medical University, Nizhny Novgorod, Russia; 2Nizhny Novgorod Regional Oncological Hospital, Nizhny Novgorod, Russia; 3A.V. Gaponov-Grekhov Institute of Applied Physics RAS, Nizhny Novgorod, Russia; 4Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia
Abstract
The most important problem of intensive care for critically ill patients with the development of a systemic inflammatory response is the obvious lack of effective clinical and laboratory tools for diagnosing of microcirculatory disorders in organs and tissues. It is worth noting that diagnostics and therapy of already existing macro-vascular complications does not guarantee recovery of microcirculation and sufficient regeneration of perfusion in hypoxic organs, which is confirmed by current trends in maintaining high mortality rates in critically ill patients with the manifestation of shock and multiple organ failure (MOF). Therefore, it is necessary to develop new clinical tools for direct diagnostics of microcirculatory disorders to identify effective criteria for predicting the manifestation/progress of MOF and timely provision of targeted efficacy therapy.
The aim of the study is to determine the possibility of using optical coherence tomography angiography (OCT-A) as a clinical bedside method for diagnosing microcirculatory disorders when monitoring the sublingual vessels perfusion of critically ill patients.
Based on the results of pilot clinical studies, the possibility of OCT-A to detect the microcirculation changes was demonstrated and a correlation of OCT-A characteristics with indicators of general clinical methods was established for moderate blood loss in patients during surgical treatment of malignant neoplasms.
The study was funded by the Russian Science Foundation, grant # 25-75-10160.
Speaker
Anton A. Plekhanov
Privolzhsky Research Medical University, Nizhny Novgorod
Russia
Discussion
Ask question
