Hybrid nanomaterials for optical heating and temperature monitoring in biological objects

Abstract

Temperature monitoring at the nanoscale plays a crucial role in biomedicine. Temperature variations affect mechanisms of cell death, such as apoptosis and necrosis, as well as cellular functions like gene expression, cell division, growth factor activities and metabolism. However, without precise temperature control, it is difficult to effectively use optical and laser techniques in nanomedicine. Therefore, real-time monitoring of temperature during optical heating is essential to avoid unwanted side effects related with overheating.
This report presents innovative hybrid materials developed for temperature monitoring in biological systems subjected to laser-induced heating. The report discusses the application of optically detected magnetic resonance in nanodiamonds with nitrogen vacancy centers for temperature control during photoinduced delivery of bioactive compounds and photothermal therapy. Additionally, the use of gold-coated nanodiamonds for photothermal therapy was shown to effectively inhibit tumor growth in laboratory animals. Research also explored plasmonic and all-dielectric nanostructures, leading to the development of advanced hybrid nanomaterials that enable simultaneous optical heating and temperature monitoring using the Stokes shift of Raman scattering.
In conclusion, this research opens up new opportunities for improved thermal control in nanomedicine, which could potentially reduce overheating-related side effects during treatment. These findings emphasize the potential of this innovative approach for both temperature monitoring and therapy in biological systems.

Speaker

Elena Gerasimova
ITMO University
Russian Federation

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