Synthesis of an anthracycline antibiotic delivery platform and evaluation of sustained release

Abstract

Malignant neoplasms remain a serious problem worldwide, requiring improved approaches to chemotherapy. Cytostatic drug delivery platforms offer several advantages, including control over the rate of drug release and the ability to increase its concentration in the pathological area. Mitoxantrone (MTX) is a synthetic cytostatic drug developed as an analogue of doxorubicin as part of research to identify new drugs with a similar spectrum of action but with reduced cardiotoxicity. The lack of convenient methods for monitoring the concentration of released substances in biofluids significantly slows down the development, optimization and testing of new prolonged release systems (including in combination with targeted delivery, controlled release, etc.). The development of accessible, sensitive methods for monitoring drug concentrations is an urgent task for medicine.
We selected the optimal conditions for efficient loading of MTX and evaluated the prolonged release from multilayer biodegradable films based on polyglycolic acid. The release of MTX was studied in various environments, including biological fluids. To evaluate the prolonged release, an approach based on the quenching of the luminescence of quantum dots was used in this work. It was shown that this method allows determining the release of the drug in various environments with high sensitivity and reliability. Thus, the proposed platform for the delivery of the cytostatic drug mitoxantrone can be promising for drug delivery. The use of a convenient, easy-to-use and sensitive method for monitoring MTX for studying the release from prolonged release systems is considered.
The work is supported by the Russian Science Foundation (project 23-13-00380).

Speaker

Daria Tsyupka
Saratov State University
Russia

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