Acoustoelectronic biosensors based on thin Langmuir Blodgett films
Ilya A. Gorbachev Institute of Radioengineering and Electronics RAS, Moscow, Russia
Andrey V. Smirnov Institute of Radioengineering and Electronics RAS, Moscow, Russia
Vladimir V. Kolesov, Institute of Radioengineering and Electronics RAS, Moscow, Russia
Iren E. Kuznetsova, Institute of Radioengineering and Electronics RAS, Moscow, Russia
Abstract
Currently, sensor technology is a rapidly developing field of science. The main strategy for its advancement lies in increasing the selectivity and sensitivity of sensor devices. This can be achieved through the development of new highly selective materials and their subsequent application as selective sensor coatings.
One of the promising approaches for creating such materials is the Langmuir–Blodgett (LB) technique. This method allows for the formation of ordered films with tunable thickness, composition, and supramolecular organization, providing predefined sensitivity and selectivity toward target molecules. A significant advantage of this approach is the possibility of modifying the coatings by incorporating individual ions or large macromolecules into the film structure.
The present study focuses on investigating the sensor properties of ordered Langmuir–Blodgett films using acousto-electronic technology. It demonstrates the feasibility of employing LB films as selective coatings for acousto-electronic sensors operating on various types of acoustic waves. For this purpose, enzyme molecules—alcohol oxidase and glucose oxidase—were incorporated into Langmuir monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine. The resulting enzyme-containing monolayers were transferred onto lithium niobate-based acoustic delay lines. Both surface acoustic wave (SAW) and plate acoustic wave (PAW) devices were employed.
The formed films exhibited sensitivity to glucose in aqueous solutions within a concentration range of 0 to 1 mg/mL. The sensor coating containing alcohol oxidase showed sensitivity to ethanol and methanol vapors over a wide concentration range. As a result, the applicability of acousto-electronic technology for the development of biosensors for alcohol vapors and aqueous glucose solutions has been successfully demonstrated.
This work was supported by the Ministry of Science and Higher Education of the Russian Federation (State Assignment FFWZ-2025-0001).
Speaker
Gorbachev Ilya A.
IRE Kotelnikova RAS
Russia
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