Alloyed quantum dots as a nanosensor for doxorubicin detection in plasma
Svetlana A. Mescheryakova1, Daniil D. Drozd1, Olga A. Goryacheva1, Irina Yu. Goryacheva1. 1Saratov State University, Saratov, Russia.
Abstract
Doxorubicin (Dox) is a highly efficacious pharmaceutical agent belonging to the group of anthracycline antibiotics. Despite its high efficacy against many types of cancer, Dox exhibits a significant number of side effects, including high cardio-, cyto- and neurotoxicity. The toxic effect of Dox is attributable to its capacity to inhibit DNA and RNA synthesis. Consequently, the concentration of Dox in the body of a patient undergoing chemotherapy must be meticulously monitored. The propensity of Dox for self-association, when considered in conjunction with the variable properties of Dox depending on the environment, results in the monitoring of patients during chemotherapy being complex and expensive. In this study, an alternative method for Dox detection in human plasma using a turn-off luminescence nanosensor based on alloyed CdZnSeS/ZnS quantum dots was demonstrated. The present study focused on the luminescence quenching of quantum dots in the presence of Dox, and optimal analytical conditions were selected for the study. The calculated detection limit was determined to be 0.02 μg/mL. The detection of Dox in human plasma was performed and a comparison was made with other methods for the detection of drugs. The findings of the alternative method are consistent with those obtained by high-performance liquid chromatography.
Speaker
Svetlana A. Mescheryakova
Saratov State University
Russia
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