Non-destructive control of tablet dosage forms using digital colorimetry and near-infrared spectroscopy methods
Oleg E. Emelyanov1, Vasiliy G. Amelin1,2;
1Vladimir State University named after Alexander and Nikolay Stoletovs, Vladimir, Russia; 2The Russian State Center for Animal Feed and Drug Standardization and Quality, Zvenigorodskoye Shosse, Moscow, Russia
Abstract
Quality and authenticity control of pharmaceutical products remains a priority task in pharmaceutical analysis. Standard analytical methods (HPLC, GC, NMR, capillary electrophoresis, UV and fluorescence spectroscopy) require sample preparation, the use of toxic solvents, and expensive equipment, which limits their application in rapid analysis and at the incoming control of blister-packaged products.
The application of non-destructive methods of digital colorimetry and near-infrared spectroscopy (4000–10000 cm⁻¹) for the evaluation of tablet forms without opening the blister packaging is considered. Colorimetric analysis was performed using a smartphone and a 3D-printed device with installed IR and UV LEDs (850 and 390 nm). For fluorescent drugs (fluoroquinolones, some NSAIDs, macrolides), the intensity of both their own fluorescence and diffuse reflection of IR radiation was used as the analytical signal, while for non-fluorescent drugs, only the diffuse reflection of IR radiation was used. The data processing was carried out using chemometric algorithms.
A high degree of agreement between the results obtained by digital colorimetry and near-infrared spectroscopy was demonstrated in the identification of the manufacturer and the determination of the active ingredient content in tablets.
Speaker
Oleg Eduardovich Emelyanov
Vladimir State University named after Alexander and Nikolay Stoletovs
Russia
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