FORMATION OF MULTISCALE STRUCTURES BASED ON ORGANIC AND INORGANIC NANOMATERIALS FOR CREATING PASSIVE AND ACTIVE IMPLANTABLE DEVICES STIMULATING NERVE TISSUES
Denis T. Murashko1, Evgeny P. Kitsyuk2, Mikhail A. Saurov2, Alexander Yu. Gerasimenko1,3
1National Research University of Electronic Technology MIET, Shokin Square 1, 124498 Zelenograd, Moscow, Russia;
2Scientific-Manufacturing Complex “Technological Centre”, Shokin Square 1, Zelenograd, 124498 Moscow, Russia
3I.M. Sechenov First Moscow State Medical University, Bolshaya Pirogovskaya street 2-4, 119991 Moscow, Russia;
Abstract
The paper presents the results of a study of the morphological and electrical characteristics of multiscale structures based on organic and inorganic nanomaterials for the creation of passive and active implantable devices stimulating nerve tissues. A technology is proposed for the formation of a multiscale structure combining a laser-modified metal surface as a microstructure and layer-by-layer deposited carbon nanotubes as a nanostructure. Thus, the following types of samples were formed: a substrate made of AISI 321 stainless steel (1) served as a control sample; a substrate made of stainless steel with a surface modified by laser radiation with a power of 4.3 W (2); a substrate with a modified surface and carbon nanotubes (3). Morphology studies of samples 2 and 3 showed the formation of a cellular structure on the surface of the stainless steel substrate. The height of one cell was ~50 μm. Nanotubes were applied by layer-by-layer spray deposition and formed a uniform layer 1 μm thick. The impact of laser radiation ensured the formation of connected branched nanostructures. The electrical conductivity of the studied samples was in the range of 7.9-8.4 S/cm. The obtained samples were used as electrodes for stimulation of nervous tissue. During cyclic electrochemical studies it was found that control samples showed the presence of oxidation-reduction reactions on the electrode surface in the range of -200 – 200 mV. At the same time, samples 2 and 3 did not show signs of chemical reactions in the same range. These results can be explained by the presence of high (~13 wt.%) oxygen content in the substrates obtained after exposure to laser radiation.
The work was carried out as part of a major scientific project with financial support from the Russian Federation represented by the Ministry of Science and Higher Education of the Russian Federation under agreement No. 075-15-2024-555 dated April 25, 2024.
Speaker
Denis T. Murashko
National Research University of Electronic Technology MIET
Russia
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