The system for controlling the dynamics of particles and cells using rotating conical electric fields

Abstract

At the cusp of now the microfabrication of biomaterials represents a promising field at the intersection of biotechnology, materials science, biomedicine and biophotonics. One of the approaches to microfabrication is the self-assembly of particles at the kinetic level driving by external rotating electric fields. By tuning the applied fields it becomes possible to create various predefined structures, tissues and organ-like systems in the future. The work contains a previously made 2D experimental system and the concept of novel setup for 3D self-assembly. This report is devoted to the development of a biotechnical system that generates a conical electric field to control the dynamics of objects and enable their microfabrication. Here we will present computer simulations used to determine the geometric and physical parameters of electrode cells. In addition, the development of the electrical part of the system will be shown, as well as the final design of the resulting experimental setup. The functionality of the system will be validated through experiments with colloidal suspensions under various operating regimes. Colloids were chosen as model systems for cellular spheroids, as they allow for real-time research in the micrometer range. We believe that the ability to control the dynamics of particles and cells in this system will represent a step toward the creation of new bio- and biocompatible materials to solve current problems in biophotonics and tissue engineering.

Speaker

Aleksandra V. Kokhanovskaia
Bauman Moscow State Technical University, Moscow, Russia
Russia

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