Determination of the structure and separation of regioisomeric pyridyl-containing aminochromencarbonitriles by spectral and chromatographic methods
Adel' P. Krivenko
Abstract
One-dimensional (1H, 13C) and two-dimensional (HSQC, HMBC) spectroscopy methods have established the structure and ratio of isomers of 4,8-C-substituted phenyl (phenylmethylidene), pyridyl (pyridylmethylidene) aminochromencarbonitriles. The individual isomers obtained by separating their mixture using high-performance liquid chromatography are characterized spectrally. Using the NMR spectra of 1H, HSQC and NMVS, it was found that the iodomethylation of the obtained aminochromencarbonitriles proceeds selectively with the participation of the nitrogen atom of the pyridine fragment with the formation of the corresponding water-soluble mono-, diiodmethylates. Among the new substances obtained, compounds exhibiting antibacterial activity were isolated.
Speaker
Alexandr Vladislavovich Nikulin
Saratov State University
Russian Federation
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