Study of the relationship between changes in blood microrheology and the hemostatic system in age-associated diseases of the cardiovascular system

Abstract

Cardiovascular disease (CVD) is the leading cause of death worldwide, and its prevalence increases significantly with age. Understanding the mechanisms underlying age-associated CVD is critical to developing effective prevention and treatment strategies. This work is devoted to the analysis of the relationship between the microrheological parameters of blood cells and the hemostasis system in patients suffering from age-associated CVD.
The volumetric concentration of RBC aggregates formed during spontaneous aggregation in the first 10 seconds (M-index) correlates with the width of the RDW-CV distribution (r=0.41) and RDW-SD distribution (r=0.4). This result suggests that with an increase in the width of the distribution of RBCs, the aggregation of RBCs increases, which may negatively affect the viscosity of the blood and, as a consequence, its flow.
Correlation analysis of the parameters of the distribution width of RBCs and platelet aggregation was also carried out. The data obtained showed that the area of the thrombus and the rate of platelet aggregation weakly negatively correlate (r=-0.28; r=-0.27) with the width of the RBC distribution. It is important to take into account that these correlations were calculated on the data obtained from the patients suffering from the age-associated disease (chronic heart failure).
Understanding this relationship can help in the development of new methods for diagnosing and treating chronic diseases associated with age. Identifying such relationships can expand the capabilities of screening and monitoring of the systemic processes of microcirculation in patients suffering from age-associated CVD.

Speaker

Umerenkov Danila
Lomonosov Moscow State University
Russia

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