Device for creating concussive brain injury in rodents
Dmitry V. Tuktarov1, Dmitry A. Myagkov1, Tuzhilkin M. A.2, Ivan V. Fedosov1, Oxana V.Semyachkina-Glushkovskaya2,3; 1Institute of Physics, Saratov State University, Universitetskaya, 40,410012 Saratov, Russia, 2Department of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, Russia, 3Institute of Physics, Humboldt University, Newtonstrasse 15, 12489, Berlin, Germany
Abstract
Traumatic brain and spinal cord injuries (TBI/SCI) involve alterations or
dysfunctions in brain function or brain pathology resulting from external
trauma. These injuries are considered serious due to their complexity and the
extensive consequences they entail, including tissue damage, necrosis, and
axonal degeneration. A controlled concussion (CC) is a neurotrauma model that
employs an impact system to produce graded, reproducible damage to the dura
mater of the subject, closely mimicking the physiological, histological, and
behavioral characteristics of closed TBI/SCI. This model generates mild to
severe TBI/SCI similar to those observed in humans. The CC utilizes an
electronic pneumatic piston, but our laboratory has developed an electromagnet-
based device. This innovation allows for more precise control of the impact
force and delay time, making the device safer, easier to operate, and maintain.
This model offers a simple and accurate method for investigating the effects and
potential treatments of TBI/SCI. The CC device enables the creation of TBI/SCI
to facilitate the study of mechanisms involved in the acute and chronic post-
traumatic periods and the development of effective therapeutic strategies. This
contusion TBI/SCI technology is particularly valuable for research on neuronal
death, cerebral edema, vascular injury, morphological changes in central
nervous system tissue, and memory impairment.
The research was supported by the Russian Science Foundation(project No. 24-
45-00010)
Speaker
Tuktarov Dmitrii
Institute of Physics, Saratov State University, Universitetskaya, 40, , 410012 Saratov, Russia.
Russia
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