Mathematical modelling of the mitochondria response of cancer cells to NIR laser irradiation
Ksenia V. Tikunov1, Gleb G. Golyshev1, Edik Rafailov2 , Alexey N. Goltsov1; 1MIREA - Russian Technological University, Moscow, Russia; 2Aston University, Birmingham, UK.
Abstract
This work is devoted to the mathematical model development of the near-infrared laser radiation action on cancer cells in order to study the molecular mechanisms of the therapeutic effect of laser radiation with a wavelength of 1267 nm and the development of direct laser therapy. In the direct laser therapy method, unlike photodynamic therapy, the generation of singlet oxygen, the action of which leads to apoptosis of cancer cells, occurs without introducing a photosensitizer into the tumor area. The mathematical model includes a description of the following physicochemical, molecular and cellular processes: 1) the initial process of photogeneration of singlet oxygen in the aqueous environment of the cell population, 2) a cascade of free radical reactions leading to the formation of reactive oxygen species (ROS) and 3) activation of antioxidant defense system of cells. Preliminary calculation results showed that the model satisfactorily describes the experimental data on the increase in the level of ROS in cancer cells under the 1267 nm laser radiation.
Speaker
Alexey Goltsov
RTU MIREA
Russia
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