Application of the multimodal method and device for assessing the functional state of the liver in patients with obstructive jaundice
Ksenia Y. Kandurova 1, Dmitry S. Sumin 1,2, Andrian V. Mamoshin 1,2, Elena V. Potapova 1;
1 Research and Development Center of Biomedical Photonics, Orel State University, Orel, Russia;
2 Orel Regional Clinical Hospital, Orel, Russia
Abstract
The treatment of diseases complicated by biliary obstruction remains relevant in abdominal surgery. Obstructive jaundice (OJ) is usually treated in two steps, the first being minimally invasive decompression of the biliary tract. However, in some cases, these procedures don't improve patients' condition, which can be caused by progressive liver failure (LF). Widely used diagnostic methods lack the ability to directly detect the functional state of the liver affected by OJ and LF. Biophotonic techniques such as fluorescence spectroscopy (FS) and diffuse reflectance spectroscopy (DRS) can be considered as a promising option to solve this problem.
The aim of this study was to develop and apply FS and DRS to assess the functional state of the liver in patients with OJ and to improve the prediction of the postoperative dynamics.
Multimodal measurements were performed using a 365 nm LED and a 450 nm laser diode in the FS channels and a 360-2400 nm tungsten halogen lamp in the DRS channels. The spectra were recorded with a CCD spectrometer in the 350-1000 nm range. Light was delivered through a specially designed 1 mm optical probe. The data were collected from 40 patients of the Orel Region Clinical Hospital during antegrade biliary decompression. Patients were divided into 2 groups after treatment on the basis of positive or negative postoperative dynamics. The diagnostic criteria were obtained by linear discriminant analysis and reached the values of sensitivity and specificity up to 88% and 91% for discriminating between the groups.
The obtained results are promising for the assessment of the functional state of the liver and its influence on the treatment outcome and possible introduction of the proposed method into clinical practice.
The study was supported by the Russian Science Foundation grant № 23-25-00487.
Speaker
Ksenia Kandurova
Orel State University
Russia
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