Gold nanomaterials with uniform properties: synthesis and applications

Abstract

The results of obtaining gold-based compounds are summarized. Data are presented on the use of synthesized compounds as an analytical system for monitoring drug concentration studies.
One of the approaches described, but so far little studied, is the use of the ability inherent in many antitumor antibiotics to quench the emission of luminescent probes. Promising agents for analytical systems are luminescent gold nanomaterials stabilized by various agents, since they have a number of significant advantages:
- Feasibility of use in a "dry" chemistry format - by adding an aliquot of the analyte to a dry preparation, - Luminescence in the visible range from 550 to 800 nm, which can be tailored to the specific analytical task,
- Large stock shift, which will eliminate the influence of background signals during analysis, - No toxic components in the composition, which will allow the use of these nano-objects without risks to the health of the researcher and the environment,
- Chemical and photostability, which makes it possible to store and use gold nanoclusters for a long time and at different excitation light powers.
The report presents data on the synthesis of nanoparticles and nanoclusters based on gold with various stabilizing agents. The possibility of using drug as a luminescent sensor for detecting drug by changes in luminescence intensity has been demonstrated. The developed approach made it possible to detect the drug with a detection limit of 7 μM.
The work was supported by the Russian Science Foundation (grant 23-73-01171).

Speaker

Anna M. Abramova
Saratov State University, Saratov, Russia
Russia

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