Early-photon mesoscopic fluorescence molecular tomography: Potential ways to increase the depth sensitivity
Alexander B. Konovalov1, Vitaly V. Vlasov1, Sergei I. Samarin1, Ilya D. Solovyev2, Daria K. Tuchina3,4, Alexander P. Savitsky2, Valery V. Tuchin3,4,5:
1 FSUE “Russian Federal Nuclear Center – Zababakhin All-Russia Research Institute of Technical Physics,” Snezhinsk, Russia
1 FSUE “Russian Federal Nuclear Center – Zababakhin All-Russia Research Institute of Technical Physics,” Snezhinsk, Russia
3 Science Medical Center, Saratov State University, Saratov, Russia
4 Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, Tomsk, Russia
5 Institute of Precision Mechanics and Control, FRS “Saratov Scientific Centre of the RAS”, Saratov, Russia
Abstract
The potential of early-photon mesoscopic fluorescence molecular tomography (EP-mFMT) to reconstruct fluorescent inclusions at relatively large depths (to 9 mm) is investigated. The paper describes a physical experiment conducted to reconstruct a phantom with a fluorophore generating rows of 0.5-mm-diam cylindrical periodic spatial structures at depths 3, 5, 7 and 9 mm. Since for the selected density of source-detector positioning (1.4 mm between the nearest source and detector), only structures at the depth of 3 mm were reconstructed successfully, the authors aimed to study possibilities to improve depth sensitivity. Our numerical experiment shows that the source-detector density increased by 4 times (high-density EP-mFMT) allows successful reconstruction of structures at the depth of 5 mm. Other potential ways to enhance depth sensitivity are also discussed. These are the choice of alternative conditions for sensitivity function calculation by the Monte Carlo method and the optical clearing of the object.
Speaker
Alexander B Konovalov
FSUE “Russian Federal Nuclear Center – Zababakhin All-Russia Research Institute of Technical Physics
Россия
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