OCT-based complementary mapping of osmotically-induced strains and attenuation coefficient
Aleksander A. Sovetsky1, Yulia.A. Alexandrovskaya2, Alexander L. Matveyev1, Lev A. Matveev1, Peter A. Chizhov1, Vladimir Y. Zaitsev1; 1A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia; 2Terra Quantum, Munich, Germany
Abstract
The usage of multimodal optical coherence tomography (OCT) is reported for observation of osmotically-induced interframe strains and the complementary variations in the spatial distribution of the optical attenuation coefficient (OAC) maps. To map the osmotic strains we used an emerging high-sensitivity OCT modality termed Optical Coherence Elastography (OCE). OCE based on processing of phase-sensitive OCT scans was realized using an OCT setup designed and manufactured at the Institute of Applied Physics, RAS. To estimate axial strains, we use the phase-resolved approach based on finding interframe phase-variation gradients by applying the vector method also developed at IAP RAS. Among the method advantages is its high robustness with respect to both additive measurement noises and speckle noise intrinsic to OCT scans. In the reported experiments, the use of homogeneous polyacrilamide gels with various degrees of cross-linking allowed us to explore the penetration rates of 50% glycerol solutions by OCT-based imaging in non-contact mode. In parallel to visualization of osmotic strains, spatially resolved variations in the attenuation coefficient was also performed. Such complementary multimodal imaging enables new insights in the processes of osmotic agent penetration. The results demonstrate that the OAC and OCE techniques can be used for studying the diffusion of osmotically active solutions for perspective applications in medicine (e.g. for diagnosing cartilage degradation) and cosmetology. The depth-resolved attenuation coefficient and the magnitude of the inter-frame deformations can be used in further studies of complementary variations in mechanical and optical parameters of tissues subjected to impregnation of osmotically active solutions. The study was supported by RSF grant No 23-72-01107.
Speaker
Aleksander A. Sovetsky
A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences
Russia
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