Measuring techniques and devices based on infrared spectroscopy for medical and ecological applications
Igor L Fufurin
Andrey N Morozov
Dmitry R Anfimov
Pavel V Platonov
Ivan B Vintaikin
Pavel P Demkin
Bauman Moscow State Technical University, Moscow, Russia
Abstract
The paper presents a measuring complex for determining the chemical composition of substances by infrared laser spectroscopy. The complex is designed to conduct scientific research and solve a wide range of applied problems, including fundamental studies of the absorption laser spectroscopy, diffuse reflectance spectroscopy; biomedical research to solve the problems of non-invasive diagnosis of human health by exhaled air, body surface and tissue condition, research in the field of hyperspectral imaging spectroscopy with quantum cascade lasers spectroscopy of surfaces and media to solve safety and medical problems; monitoring of environmental pollution, etc.
The device includes a quantum cascade laser tunable in increments of 2 cm-1 in the mid-infrared range with a tuning range width of about 200 cm-1 and a peak power of about 250 mW. The sensitivity using a multipass gas (about 30 m path) cell is about 50 ppb. Matching optics for diffuse reflectance spectroscopy is designed for focal lengths of 40 mm and 300 mm. The diffuse reflectance sensitivity is 0.1-1.0 mg/cm2. The information and measurement complex of absorption spectroscopy is designed in a stationary form, and the diffuse reflectance spectroscopy system is portable (no more than 10 kg). The possibilities of using infrared Fourier spectroscopy to solve the problems of gas analysis and identify the main biomarker molecules, especially mental diseases (schizophrenia, major depressive disorders, bipolar disorders) and oncological diseases of the genitourinary system are shown. Socially significant diseases, such as diabetes mellitus, asthma and other immune-mediated diseases, cause serious damage to society and the state, and have a high incidence. The described software and hardware solutions can be a useful tool for the development of personalized medicine techniques.
Speaker
Igor Fufurin
Bauman Moscow State Technical University
Russia
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