Nanocomposites based on silica-coated gold nanostars for controlled delivery of antitumor drugs
Vitaly A. Khanadeev,1,2 Andrey V. Simonenko,1,3 Andrey M. Burov,1
1 Institute of Biochemistry and Physiology of Plants and Microorganisms – Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), Saratov, Russia;
2 Saratov State University of Genetics, Biotechnology and Engineering Named after N. I. Vavilov, Saratov, Russia;
3 Saratov State University, Saratov, Russia;
Abstract
Recently, methods of targeted drug delivery based on nanomaterials have significantly developed. This has opened up new opportunities for the therapeutic use of drugs that previously caused significant side effects. The use of targeted drug delivery systems with controlled release can reduce the negative impact of drugs on the entire body and increase the effectiveness of treatment.
In this work, we synthesized and studied nanocomposites based on gold nanostars with a hollow shell of organic silica as carriers for drug delivery. Two types of drugs, docetaxel and doxorubicin, were loaded into the cavity formed by etching inside the silica shell. To implement controlled release, the nanocomposites were coated with a molecular gate, tetradecanol. It was found that the drug was retained inside the nanocomposites until an external stimulus was received.
This research was supported by the Russian Science Foundation, grant No. 23-22-00354,
https://rscf.ru/en/project/23-22-00354/.
Speaker
Vitaly A. Khanadeev
Institute of Biochemistry and Physiology of Plants and Microorganisms – Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), Saratov, Russia; Saratov State University of Genetics, Biotechnology and Engineering named after N. I. Vavilov, Saratov, Russia;
Russia
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