Nanocomposites based on gold nanorods with a hollow silica shell for biomedical applications
Maria A. Marinina1,2, Daria V. Manushina1,2, Andrey V. Simonenko1,3, Andrey M. Burov1, Vitaly A. Khanadeev1,2;
1 Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), Saratov, Russia;
2 Saratov State University of Genetics, Biotechnology and Engineering named after N.I. Vavilov, Saratov, Russia;
3 Saratov State University, Saratov, Russia
Abstract
Recently, gold nanorods have attracted special attention due to their unique surface plasmon resonance, which can be tuned in the range of the first therapeutic window, which corresponds to wavelengths of 650-1150 nm. This is very important for the biomedical application of nanorods. Also, various nanocomposites for SERS, photothermal and photodynamic therapy, and drug delivery are created based on nanorods. In this work, gold nanorods coated with a silica shell of varying thickness were synthesized. Then, the resulting nanocomposites with a thick shell were etched with surface protection. Due to this, cavities were obtained inside the silica shell. These cavities can be used to load various substances, for example, drugs that have a large number of side effects. The use of such systems will reduce the negative effect on the entire body. Thus, the resulting nanocomposites can be used for drug delivery.
This work was supported by the Russian Science Foundation, grant No. 23-22-00354,
https://rscf.ru/en/project/23-22-00354/.
Speaker
Marinina Maria Alekseevna
Saratov State University of Genetics, Biotechnology and Engineering named after N.I. Vavilov, Saratov, Russia
Russia
Discussion
Ask question
