Temperature-sensitive drug delivery system based on gold nanostars coated with etched silica shell and tetradecanol
Andrey V. Simonenko1,2, Andrey M. Burov1, Vitaly A. Khanadeev1,3;
1 Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), Saratov, Russia;
2 Saratov State University, Saratov, Russia;
3 Saratov State University of Genetics, Biotechnology and Engineering named after N.I. Vavilov, Saratov, Russia
Abstract
In recent years, controlled-release drug delivery systems have attracted much interest. Such systems use various molecules that coat the surface of the nanocarrier and prevent the drug from being released until an external signal occurs. Both physical and chemical stimuli can act as an external signal. Thanks to such a system, the drug can be released at a selected location and time, which will improve the effectiveness of treatment. In this work, nanocomposites based on gold nanostars coated with an etched silica shell and tetradecanol were studied for controlled-release drug delivery. Docetaxel was used as the drug, which was loaded into the cavities formed by etching. Tetradecanol acted as a thermosensitive molecular gate, which solidified at room temperature and closed the pores in the etched silica shell. It was found that the drug was retained in the nanocomposites until an external stimulus in the form of heating was applied.
This research was supported by the Russian Science Foundation, grant No. 23-22-00354,
https://rscf.ru/en/project/23-22-00354/.
Speaker
Simonenko Andrey Victorovich
Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences (IBPPM RAS),Saratov, Russia; Saratov State University, Saratov, Russia
Russia
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