Multifunctional Wound Care Platfroms Based on Microchamber Technology for Tailored Modulation of Wound Physiology
Ekaterina V. Lengert1,2, Angelina A. Savkina2, Tatiana V. Stepanova2, Olga I. Guslyakova3,4, Ekaterina S. Prikhozhdenko4, Valentina O. Plastun4, Gleb B. Sukhorukov3,5,6, Alexey N. Ivanov2, Alexey V. Ermakov1,2,6;
1I.M. Sechenov First Moscow State Medical University, Moscow, Russia
2Saratov State Medical University of V.I. Razumovsky, Ministry of Health
of the Russian Federation, Saratov, Russia
3Skolkovo Institute of Science and Technology, Moscow, Russia
4Saratov State University, Saratov, Russia
5Queen Mary University of London, London, UK
6Life Improvement by Future Technologies (LIFT) Center, Moscow, Russia
Abstract
Wound management remains a significant healthcare challenge, with escalating associated costs. Developing advanced wound dressings that can actively modulate the wound microenvironment to promote healing is a crucial area of research. This study presents the fabrication and evaluation of novel microchamber-based smart wound dressings designed for the sustained and regulated release of bioactive compounds.
The microchamber-based dressings were fabricated using polylactic acid and hydrogel support, enabling the encapsulation of active compounds. The dressings were loaded with the polyphenolic antioxidant tannic acid and sodium percarbonate, a precursor that generates hydrogen peroxide in situ. This unique cargo encapsulation technique facilitates the sustained release of the challenging agent H2O2 within the wound bed.
The in vitro and in vivo performance of the microchamber dressings was extensively evaluated, revealing the kinetics of cargo release and the resulting bioeffects on the antioxidant protection system, inflammation, and angiogenesis throughout the wound healing process. Morphological analysis of wounds treated with the microchamber-based dressings loaded with active compounds demonstrated control over physiological processes in wounds, as well as accelerated healing compared to control treatments.
The ability of the microchamber-based smart wound dressings to modulate the chemical microenvironment of the wound through the controlled release of active compounds represents a promising approach for improving wound healing outcomes. The development of this technology highlights the potential of advanced materials and encapsulation strategies to actively regulate the wound milieu and provide sustained, tailored therapeutic delivery. Further research is warranted to expand the range of factors that can be corrected with microchambers and to explore the clinical translation and broader applications of this technology for wound management.
Speaker
Ekaterina Lengert
Institute of Molecular Theranostics, I.M. Sechenov First Moscow State Medical University, 8 Trubetskaya Str., 119991 Moscow, Russia
Russia
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