Gold nanoparticles coupled with tumor antigens have an immunomodulatory impact
Roman D. Vyrshchikov, Sergey A. Staroverov, Lev A. Dykman
Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences, Saratov, Russia
Abstract
Research on the development of an immune response in the presence of gold nanoparticles as adjuvants enables assessment of their potential in the development of next-generation vaccines. It is possible to create therapeutic and preventative antitumor vaccine prototypes using gold nanoparticles coupled to cancer markers. Here, we separated and coupled tumor cell line-produced antigens to gold nanoparticles. Animals were immunized with the conjugates, and markers of the immunological response were noted. Investigations were conducted on the conjugates' effects on tumor growth, implantability, and protective value during animal vaccination.
Speaker
Vyrshchikov R.D.
Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences
Russia
Discussion
Ask question
