Effect of doxorubicin on the photoluminescent properties of AgInS2/ZnS quantum dots in the presence of bovine serum albumin
Vera V. Olomskaya, Yulia A. Kornysheva1, Irina Yu. Goryacheva1; 1Saratov State University, Saratov, Russia
Abstract
Doxorubicin (Dox) is one of the most effective chemotherapeutic agents for the treatment of wide range of malignant neoplasms. However, the use of doxorubicin has been limited by a dose-related and irreversible cardiotoxicity as well as by the emergence of drug resistance. Therefore, there is a need to track its exact content in the human body.
AgInS2/ZnS ternary quantum dots have bright fluorescence, biocompatibility, and the ability to interact with drugs through ligands on the surface. Due to these qualities of quantum dots, monitoring the concentration of doxorubicin through fluorescence quenching of quantum dot fractions is promising. Adding bovine serum albumin, which is an element of biological fluids, to the model system makes it possible to increase the reliability of the experimental results.
The aim of the study is to analyze the photoluminescent properties of the ternary system — quantum dots (QD)/doxorubicin (Dox)/bovine serum albumin (BSA).
During the study, fractions of QD of the AgInS2/ZnS composition were obtained in the emission range from 611-517 nm with a maximum quantum yield y of 56%. It was revealed that the highest sensitivity to quenching was observed in fraction No. 4 (λmax = 480 nm)., Kb = 1.02 *10-6 M, with LOD = 0.25 *10-6, M. The efficiency of quenching the photoluminescence of fraction No. 4 quantum dots in the presence of doxorubicin and bovine serum albumin was assessed. Kb = 1.3 *10-6, M, and LOD = 1.9 *10-6, M.
Speaker
Vera V. Olomskaya
Saratov State University, Saratov, Russia
Russian Federation
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