Laser synthesis of magnetic nanoparticles based on iron in various media

Abstract

Currently, laser methods of nanoparticle synthesis for biomedical applications are being actively developed. The use of femtosecond laser ablation and fragmentation in a liquid medium makes it possible to obtain magnetic, photosensitized nanoparticles, as well as their hybrid forms. By changing the environment and experimental conditions, it is possible to control the structure and properties of the laser methods. The use of magnetic nanoparticles as theranostic agents is attracting increasing attention due to their exceptional capabilities in controlled magnetic guidance, magnetic resonance imaging, hyperthermia and other areas of biological applications.
The radiation sources in the experiments were femtosecond and nanosecond laser systems, scanning with a laser beam over the target surface was carried out using a galvanoscanator. Fe nanoparticles were synthesized using laser radiation in an atmospheric environment, in high-purity argon, in an environment of ethyl alcohol, deionized water, and chemically pure acetone. Fe3O4 nanoparticles were obtained in an oxygen environment, in a deionized water environment. Combined Fe+Au nanoparticles were synthesized by ablation of a target of chemically pure iron in a colloidal solution of Au nanoparticles.
The obtained nanoparticles, including in colloidal solutions, were subjected to studies of their sizes using scanning electron microscopy, transmission electron microscopy. An elementary analysis of synthesized nanomaterials and substrates used for synthesis by energy dispersion analysis has been performed. The synthesized nanoparticles were also studied by X-ray fluorescence diffractometry. Optical transmission spectra data were obtained by optical spectrophotometry. Studies have been conducted on the cytotoxicity of a number of colloidal solutions of nanoparticles.
This study was funded by the Russian Science Foundation (project no. 22-79-10348, https://rscf.ru/project/22-79-10348/).

Speaker

Kirill Khorkov
Vladimir State University
Russia

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