A New Model of DNA-Water Interaction: Dynamic Chromatin Self-Organization as the Basis of Cellular Logic
Ivan V. Savelev1, Michael M. Rempel1, Alexandr V. Vikhorev1, Oksana O. Polesskaya1, Richard Alan Miller1, Alexandr V. Vetcher2 and Max V. Myakishev-Rempel1
1 DNA Resonance Research Foundation, San Diego, CA, USA, ivan.savelyev23@gmail.com, mikerempel3@gmail.com, vikhall14@gmail.com, opolesskaya@gmail.com, rick@richardalanmiller.com, max@dnaresonance.org
2 Russian Peoples Friendship University & Shishonin Integrative Health Clinic, Moscow, Russia
*Correspondence: MVM, max@dnaresonance.org
Abstract
This paper presents a novel model of DNA-water interactions and their potential role in chromatin organization. The core idea of the model is a perpetual dynamic interplay between the tendency towards order (perfection) and the continuous disassembly of that order (imperfection) as a fundamental principle of life. Our model proposes that DNA may initiate microcrystallization of water, imprinting its sequence onto the water structure through a process we term "crystal pattern propagation." We suggest that DNA imprints its sequence into nucleoplasm water by defining the shifting pattern of surrounding transverse water layers, creating a unique water structure that reflects the underlying DNA sequence. The model emphasizes a constant interplay between the formation of ordered, crystal-like water structures and their continuous dissolution and reformation. We propose that nucleoplasm exists in a state of continuous dynamic reorganization with three main components: recrystallization of polywater, screw oscillations of DNA, and chromatin dynamics. A key implication of the model is that sequence-specific chromatin refolding is the primary mechanism by which cells process information. This dynamic reorganization of chromatin, guided by DNA-water interactions, may serve as a physical basis for cellular logic and decision-making. The model also offers a new perspective on the function of repetitive DNA sequences and introns. It is proposed that these elements play a crucial role in gene expression regulation through specific interactions between DNA segments and control of chromatin compaction. This may explain the retention of large amounts of non-coding DNA in the genome and suggests a new mechanism for coordinating gene expression. Genomic analysis has provided some support for the model's predictions, but further experimental validation is needed. The model opens up new avenues for research in cellular biology, biophysics, and potentially cognitive science, offering novel approaches to understanding genome organization and gene regulation.
Speaker
Max Myakishev-Rempel
DRRF
United States
Discussion
Ask question
