Biaxial Mechanical Properties of Sheep Myocardium
Thanyani pandelani1, Makhosasana Msibi1, Israel Mabuda1, Lebogang Mathebela1,2 and Letlhogonolo Semakane1,2, Harry Ngwangwa1 and Fulufhelo Nemavhola2
1 Unisa Biomedical Engineering Research Group, Department of Mechanical, Bioresources and Biomedical Engineering, School of Engineering and built environment, College of Science Engineering and Technology, University of South Africa, Pretoria, 0001, South Africa
2 Faculty of Engineering and the Built Environment, Durban University of Technology, Durban, South Africa
Abstract
This study investigates the passive biaxial mechanical properties of sheep myocardium, focusing on the left ventricle (LV), right ventricle (RV), and mid-wall (MDW) regions. Understanding the mechanical behavior of these myocardial tissues is critical for elucidating cardiac function and potential failure mechanisms.
A total of ten sheep hearts were procured and prepared for biaxial mechanical testing. Samples were subjected to equi-biaxial stretching in both longitudinal and circumferential directions to simulate physiological conditions. The stress-strain relationships revealed non-linear behavior across all regions, with significant differences observed between the LV, RV, and MDW tissues.
The LV exhibited the highest stiffness, particularly in the longitudinal direction, suggesting its critical role in high-pressure blood ejection. The RV, on the other hand, demonstrated the highest stored strain energy, indicating a greater capacity for deformation under load, which is essential for its role in accommodating varying blood volumes. The MDW displayed intermediate properties, providing a balance between the LV and RV functions.
Statistical analyses confirmed significant anisotropy and cross-directional variations, particularly in the RV and LV. The findings underscore the importance of regional mechanical properties in cardiac function and highlight the potential for these properties to inform the development of therapeutic strategies for heart disease.
Speaker
Thanyani Pandelani
University of South Africa
South Africa
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