Effect of permeability and wall properties on peristaltic transport of chyme in the colon
Saveliy Peshin1,2, Alex G. Kuchumov1,2, Kayvan Sadeghy3
1Biofluids laboratory, Perm National Research Polytechnic University, Perm, Russia;
2Department of Computational Mathematics, Mechanics and Biomechanics, Perm National Research Polytechnic University, Perm, Russia; 3School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran
Abstract
The intestinal barrier's functional characteristics are characterized by the colon wall's permeability. Even though there are several assays available to measure and assess intestinal permeability, more study is still required before clinical application. The results are not always very dependable because of the present methodology' complexity and lack of standardization. Numerical simulation and mathematical modeling could help solve these intestinal permeability diagnostic issues. Creating a theoretical model for peristaltic chyme transport in the colon with a porous wall is a required first step. We have run a transient 2-D FSI simulation of chyme, which is thought of as a non-Newtonian fluid with a permeable colon wall. In order to mimic fluid absorption in the intestinal wall, Darcy's law was implemented. The chyme rheology was modeled using the Sisco model. The velocity of the peristaltic wave's amplitude and velocity were used to calculate the chyme flow velocity. A region of the fluid domain forms where velocity increases to a maximum value 0.2 cm/s as the lumen decreases. The distribution of absorption rates throughout the colon's walls was ascertained using the characteristics associated with peristaltic waves. Particles in the fluid domain moved with a maximum velocity of 0.2 cm/s, while the maximum absorption velocity in the porous domain was 0.08 cm/s. Darcy's pressure changes by 2.5 times with a two-fold increase in wave propagation. Three physical phenomena can be combined in the colon by using the coupled model of fluid-structure interaction and permeability: the flow of chyme (liquid), the interaction between liquid and solid, and absorption because of permeability. It is anticipated that the influence of wave amplitude will outweigh the influence of wave speed throughout propagation.
Funding: The reported study was funded by RFBR and INSF, project number 20-58-56014.
Speaker
Saveliy Peshin
Department of Computational Mathematics, Mechanics and Biomechanics, Perm National Research Polytechnic University
Russia
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